The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice

Polyphenols are representative bioactive substances with diverse biological effects. Here, we show that apigenin, a flavonoid, has suppressive effects on microRNA (miRNA) function. The effects were mediated by impaired maturation of a subset of miRNAs, probably through inhibition of the phosphorylat...

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Detalhes bibliográficos
Main Authors: Ohno, Motoko, Shibata, Chikako, Kishikawa, Takahiro, Yoshikawa, Takeshi, Takata, Akemi, Kojima, Kentaro, Akanuma, Masao, Kang, Young Jun, Yoshida, Haruhiko, Otsuka, Motoyuki, Koike, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757358/
https://ncbi.nlm.nih.gov/pubmed/23989853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02553
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