Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function

The calcium-sensing receptor (CaR) plays an essential role in mediating Ca(2+)-induced keratinocyte differentiation in vitro. In this study, we generated keratinocyte-specific CaR knockout ((Epid)CaR-/-) mice to investigate the function of the CaR in epidermal development in vivo. (Epid)CaR-/- mice...

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Autors principals: Tu, Chia-Ling, Crumrine, Debra, Man, Mao-Qiang, Chang, Wenhan, Elalieh, Hashem, You, Michael, Elias, Peter M., Bikle, Daniel D.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434298/
https://ncbi.nlm.nih.gov/pubmed/22622426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.159
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