An In Vivo C. elegans Model System for Screening EGFR-Inhibiting Anti-Cancer Drugs

The epidermal growth factor receptor (EGFR) is a well-established target for cancer treatment. EGFR tyrosine kinase (TK) inhibitors, such as gefinitib and erlotinib, have been developed as anti-cancer drugs. Although non-small cell lung carcinoma with an activating EGFR mutation, L858R, responds wel...

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Main Authors: Bae, Young-Ki, Sung, Jee Young, Kim, Yong-Nyun, Kim, Sunshin, Hong, Kyeong Man, Kim, Heung Tae, Choi, Min Sung, Kwon, Jae Young, Shim, Jaegal
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434183/
https://ncbi.nlm.nih.gov/pubmed/22957020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042441
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