Antibody Protection Reveals Extended Epitopes on the Human TSH Receptor

Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-dependent epitopes reported to involve primarily the leucine rich repeat region of the ectodomain (LRD). However, successful crystallization of TSHR residues 22–260 has omitted important extracellular non-LRD res...

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Main Authors: Latif, Rauf, Teixeira, Avelino, Michalek, Krzysztof, Ali, M. Rejwan, Schlesinger, Max, Baliram, Ramkumarie, Morshed, Syed A., Davies, Terry F.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434159/
https://ncbi.nlm.nih.gov/pubmed/22957097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044669
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