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The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides

Although no high-resolution structural information is available for the ryanodine receptor (RyR) channel pore-forming region (PFR), molecular modeling has revealed broad structural similarities between this region and the equivalent region of K(+) channels. This study predicts that, as is the case i...

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Detalhes bibliográficos
Main Authors: Mason, Sammy A., Viero, Cedric, Euden, Joanne, Bannister, Mark, West, Duncan, Chen, S.R. Wayne, Williams, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434103/
https://ncbi.nlm.nih.gov/pubmed/22930804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210851
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