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Tuning of EAG K(+) channel inactivation: Molecular determinants of amplification by mutations and a small molecule
Ether-à-go-go (EAG) and EAG-related gene (ERG) K(+) channels are close homologues but differ markedly in their gating properties. ERG1 channels are characterized by rapid and extensive C-type inactivation, whereas mammalian EAG1 channels were previously considered noninactivating. Here, we show that...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434097/ https://ncbi.nlm.nih.gov/pubmed/22930803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210826 |
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