Human CST promotes telomere duplex replication and general replication restart after fork stalling

Mammalian CST (CTC1-STN1-TEN1) associates with telomeres and depletion of CTC1 or STN1 causes telomere defects. However, the function of mammalian CST remains poorly understood. We show here that depletion of CST subunits leads to both telomeric and non-telomeric phenotypes associated with DNA repli...

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Autors principals: Stewart, Jason A, Wang, Feng, Chaiken, Mary F, Kasbek, Christopher, Chastain, Paul D, Wright, Woodring E, Price, Carolyn M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433780/
https://ncbi.nlm.nih.gov/pubmed/22863775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.215
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