Human CST promotes telomere duplex replication and general replication restart after fork stalling

Mammalian CST (CTC1-STN1-TEN1) associates with telomeres and depletion of CTC1 or STN1 causes telomere defects. However, the function of mammalian CST remains poorly understood. We show here that depletion of CST subunits leads to both telomeric and non-telomeric phenotypes associated with DNA repli...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Stewart, Jason A, Wang, Feng, Chaiken, Mary F, Kasbek, Christopher, Chastain, Paul D, Wright, Woodring E, Price, Carolyn M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433780/
https://ncbi.nlm.nih.gov/pubmed/22863775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.215
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