Adoptive Transfer of siRNA Cblb-Silenced CD8(+) T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model

The ubiquitin ligase Cbl-b is an established regulator of T cell immune response thresholds. We recently showed that adoptive cell transfer (ACT) of cblb (−/−) CD8(+) T cells enhances dendritic cell (DC) immunization-mediated anti-tumor effects in immune-competent recipients. However, translation of...

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Main Authors: Hinterleitner, Reinhard, Gruber, Thomas, Pfeifhofer-Obermair, Christa, Lutz-Nicoladoni, Christina, Tzankov, Alexander, Schuster, Manfred, Penninger, Josef M., Loibner, Hans, Lametschwandtner, Günther, Wolf, Dominik, Baier, Gottfried
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433477/
https://ncbi.nlm.nih.gov/pubmed/22962608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044295
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