Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection

BACKGROUND: The broad applicability of RNA aptamers as cell-specific delivery tools for therapeutic reagents depends on the ability to identify aptamer sequences that selectively access the cytoplasm of distinct cell types. Towards this end, we have developed a novel approach that combines a cell-ba...

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Detalhes bibliográficos
Main Authors: Thiel, William H., Bair, Thomas, Peek, Andrew S., Liu, Xiuying, Dassie, Justin, Stockdale, Katie R., Behlke, Mark A., Miller, Francis J., Giangrande, Paloma H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433472/
https://ncbi.nlm.nih.gov/pubmed/22962591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043836
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