Evidence That Sleep Deprivation Downregulates Dopamine D2R in Ventral Striatum in the Human Brain

Dopamine D2 receptors are involved with wakefulness, but their role in the decreased alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation reduced dopamine D2/D3 receptor availability (measured with PET and [(11)C]raclopride in controls) in striatum, but could n...

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Main Authors: Volkow, Nora D., Tomasi, Dardo, Wang, Gene-Jack, Telang, Frank, Fowler, Joanna S., Logan, Jean, Benveniste, Helene, Kim, Ron, Thanos, Panayotis K., Ferré, Sergi
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433285/
https://ncbi.nlm.nih.gov/pubmed/22573693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0045-12.2012
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