Respiratory virus induced dysregulation of T regulatory cells leads to chronic rejection

BACKGROUND: Lower respiratory viral infections predispose to Bronchiolitis Obliterans Syndrome (BOS). In addition, there is emerging evidence to support the role of autoimmunity in the pathogenesis of BOS. Since CD4(+)CD25(+)Foxp3(+) T-cell (Treg) control autoimmunity, we tested the hypothesis that...

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Hauptverfasser: Bharat, Ankit, Kuo, Elbert, Saini, Deepti, Steward, Nancy, Hachem, Ramsey, Trulock, Elbert P., Patterson, G.A., Meyers, Bryan F., Mohanakumar, T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433050/
https://ncbi.nlm.nih.gov/pubmed/20971279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2010.06.048
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