Somatic HIF2α gain-of-function mutations in paraganglioma and somatostatinoma associated with polycythemia

Hypoxia inducible factors (HIFs) are transcription factors controlling energy, iron metabolism, erythropoiesis, and development, and, when dysregulated, contribute to tumorigenesis, cancer progression, and invasion. However, HIFα mutations have not previously been identified in any cancer. Here we r...

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Hlavní autoři: Zhuang, Zhengping, Yang, Chunzhang, Lorenzo, Felipe, Merino, Maria, Fojo, Tito, Kebebew, Electron, Popovic-Brkic, Vera, Stratakis, Constantine A., Prchal, Josef T., Pacak, Karel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432945/
https://ncbi.nlm.nih.gov/pubmed/22931260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1205119
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