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Somatic HIF2α gain-of-function mutations in paraganglioma and somatostatinoma associated with polycythemia
Hypoxia inducible factors (HIFs) are transcription factors controlling energy, iron metabolism, erythropoiesis, and development, and, when dysregulated, contribute to tumorigenesis, cancer progression, and invasion. However, HIFα mutations have not previously been identified in any cancer. Here we r...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432945/ https://ncbi.nlm.nih.gov/pubmed/22931260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1205119 |
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