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New Strategies in Pleural Mesothelioma: BAP1 and NF2 as Novel Targets for Therapeutic Development and Risk Assessment
Malignant pleural mesothelioma (MPM) is a highly lethal cancer with limited therapeutic options. Recent work has identified frequent inactivation of two tumor suppressor genes in MPM-- NF2 (Neurofibromatosis type 2) and BAP1 (BRCA associated protein 1). Additionally, germline mutations in BAP1 have...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432735/ https://ncbi.nlm.nih.gov/pubmed/22825583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2375 |
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