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New Strategies in Pleural Mesothelioma: BAP1 and NF2 as Novel Targets for Therapeutic Development and Risk Assessment

Malignant pleural mesothelioma (MPM) is a highly lethal cancer with limited therapeutic options. Recent work has identified frequent inactivation of two tumor suppressor genes in MPM-- NF2 (Neurofibromatosis type 2) and BAP1 (BRCA associated protein 1). Additionally, germline mutations in BAP1 have...

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Hlavní autoři: Ladanyi, Marc, Zauderer, Marjorie G., Krug, Lee M., Ito, Tatsuo, McMillan, Robert, Bott, Matthew, Giancotti, Filippo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432735/
https://ncbi.nlm.nih.gov/pubmed/22825583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2375
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