HECA-452 is a Non-Function Blocking Antibody for Isolated Sialyl Lewis(x) Adhesion to Endothelial Expressed E-selectin Under Flow Conditions

E-selectin, expressed on inflamed endothelium, and sialyl Lewis x (sLe(x)), present on the surface of leukocytes, play a key role in leukocyte–endothelial interactions during leukocyte recruitment to sites of inflammation. HECA-452 is a monoclonal antibody (mAb) that recognizes sLe(x) and is routine...

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Main Authors: Kummitha, China Malakondaiah, Shirure, Venktesh S., Delgadillo, Luis F., Deosarkar, Sudhir P., Tees, David F. J., Burdick, Monica M., Goetz, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432728/
https://ncbi.nlm.nih.gov/pubmed/22820001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2012.07.003
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