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The Major Isoforms of Bim Contribute to Distinct Biological Activities that Govern the Processes of Autophagy and Apoptosis in Interleukin-7 Dependent Lymphocytes

Bim is a BH3-only member of the Bcl-2 family that enables the death of T-cells. Partial rescue of cytokine-deprived T-cells occurs when Bim and the receptor for the T-cell growth factor, interleukin-7 (IL-7), are deleted, implicating Bim as a possible target of IL-7-mediated signaling. Alternative s...

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Библиографические подробности
Главные авторы: Ruppert, Shannon, Li, Wenqing, Zhang, Ge, Carlson, Adina L., Limaye, Arati, Durum, Scott K., Khaled, Annette R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432704/
https://ncbi.nlm.nih.gov/pubmed/22728771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2012.06.017
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