Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis

RATIONALE: Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant cle...

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Bibliographische Detailangaben
Hauptverfasser: Malur, Anagha, Kavuru, Mani S, Marshall, Irene, Barna, Barbara P, Huizar, Isham, Karnekar, Reema, Thomassen, Mary Jane
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432632/
https://ncbi.nlm.nih.gov/pubmed/22697800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-46
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