Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway

Nitroglycerin (GTN) has been clinically used to treat angina pectoris and acute heart episodes for over 100 years. The effects of GTN have long been recognized and active research has contributed to the unraveling of numerous metabolic routes capable of converting GTN to the potent vasoactive messen...

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Detalhes bibliográficos
Main Authors: Mao, Mao, Sudhahar, Varadarajan, Ansenberger-Fricano, Kristine, Fernandes, Denise C., Tanaka, Leonardo Y., Fukai, Tohru, Laurindo, Francisco R.M., Mason, Ronald P., Vasquez-Vivar, Jeannette, Minshall, Richard D., Stadler, Krisztian, Bonini, Marcelo G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432314/
https://ncbi.nlm.nih.gov/pubmed/22037515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.09.020
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