Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder

Most pathway and gene-set enrichment methods prioritize genes by their main effect and do not account for variation due to interactions in the pathway. A portion of the presumed missing heritability in genome-wide association studies (GWAS) may be accounted for through gene–gene interactions and add...

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Main Authors: Pandey, A, Davis, N A, White, B C, Pajewski, N M, Savitz, J, Drevets, W C, McKinney, B A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432194/
https://ncbi.nlm.nih.gov/pubmed/22892719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2012.80
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