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The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine

Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex regulatory networks of variants and expression of multiple genes lead to small individual-variant effects and difficulty replicating the effect o...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: McKinney, Brett A., Lareau, Caleb, Oberg, Ann L., Kennedy, Richard B., Ovsyannikova, Inna G., Poland, Gregory A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981436/
https://ncbi.nlm.nih.gov/pubmed/27513748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158016
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