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The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine

Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex regulatory networks of variants and expression of multiple genes lead to small individual-variant effects and difficulty replicating the effect o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: McKinney, Brett A., Lareau, Caleb, Oberg, Ann L., Kennedy, Richard B., Ovsyannikova, Inna G., Poland, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981436/
https://ncbi.nlm.nih.gov/pubmed/27513748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158016
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