Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice

Insulin resistance, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. This, in turn, contributes to a further damage of insulin signaling. Effectiveness of T2D treatment depends in large part on the...

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Main Authors: Horakova, Olga, Medrikova, Dasa, van Schothorst, Evert M., Bunschoten, Annelies, Flachs, Pavel, Kus, Vladimir, Kuda, Ondrej, Bardova, Kristina, Janovska, Petra, Hensler, Michal, Rossmeisl, Martin, Wang-Sattler, Rui, Prehn, Cornelia, Adamski, Jerzy, Illig, Thomas, Keijer, Jaap, Kopecky, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432031/
https://ncbi.nlm.nih.gov/pubmed/22952760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043764
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