Metastasis-associated Protein 1/Histone Deacetylase 4-Nucleosome Remodeling and Deacetylase Complex Regulates Phosphatase and Tensin Homolog Gene Expression and Function

Metastasis-associated protein 1 (MTA1) is widely overexpressed in human cancers and is associated with malignant phenotypic changes contributing to morbidity in the associated diseases. Here we discovered for the first time that MTA1, a master chromatin modifier, transcriptionally represses the expr...

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Main Authors: Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B., Molli, Poonam R., Sahni, Neil, Karanam, Narasimha Kumar, Mudvari, Prakriti, Kumar, Rakesh
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431680/
https://ncbi.nlm.nih.gov/pubmed/22700976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348474
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