GQ-16, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Promotes Insulin Sensitization without Weight Gain

The recent discovery that peroxisome proliferator-activated receptor γ (PPARγ) targeted anti-diabetic drugs function by inhibiting Cdk5-mediated phosphorylation of the receptor has provided a new viewpoint to evaluate and perhaps develop improved insulin-sensitizing agents. Herein we report the deve...

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Main Authors: Amato, Angélica A., Rajagopalan, Senapathy, Lin, Jean Z., Carvalho, Bruno M., Figueira, Ana C. M., Lu, Jenny, Ayers, Stephen D., Mottin, Melina, Silveira, Rodrigo L., Souza, Paulo C. T., Mourão, Rosa H. V., Saad, Mário J. A., Togashi, Marie, Simeoni, Luiz A., Abdalla, Dulcinéia S. P., Skaf, Munir S., Polikparpov, Igor, Lima, Maria C. A., Galdino, Suely L., Brennan, Richard G., Baxter, John D., Pitta, Ivan R., Webb, Paul, Phillips, Kevin J., Neves, Francisco A. R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431672/
https://ncbi.nlm.nih.gov/pubmed/22584573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332106
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