Aggregate Clearance of α-Synuclein in Saccharomyces cerevisiae Depends More on Autophagosome and Vacuole Function Than on the Proteasome

Parkinson disease is the second most common neurodegenerative disease. The molecular hallmark is the accumulation of proteinaceous inclusions termed Lewy bodies containing misfolded and aggregated α-synuclein. The molecular mechanism of clearance of α-synuclein aggregates was addressed using the bak...

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Hlavní autoři: Petroi, Doris, Popova, Blagovesta, Taheri-Talesh, Naimeh, Irniger, Stefan, Shahpasandzadeh, Hedieh, Zweckstetter, Markus, Outeiro, Tiago F., Braus, Gerhard H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431624/
https://ncbi.nlm.nih.gov/pubmed/22722939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361865
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