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Iodination as a probe for small regions of disrupted secondary structure in double-stranded DNAs.

Conditions were established where the thallium-catalyzed iodination of random coil DNA proceeded 100-200 times faster than for native DNA. This reaction was explored as a probe for localized regions of disrupted base pairs in duplex DNA. A heteroduplex was constructed between DNA fragments produced...

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Bibliografiske detaljer
Main Authors: Jensen, K F, Nes, I F, Wells, R D
Format: Artigo
Sprog:Inglês
Udgivet: 1976
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC343158/
https://ncbi.nlm.nih.gov/pubmed/1087408
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