Frequent amplification of a chr19q13.41 microRNA polycistron (C19MC) in aggressive primitive neuro-ectodermal brain tumors

We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45(~25%) primary CNS-PNET which results in striking over-expression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell surviv...

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Autors principals: Li, Meihua, Lee, Kyle F, Lu, Yuntao, Clarke, Ian, Shih, David, Eberhart, Charles, Collins, V. Peter, Van Meter, Tim, Picard, Daniel, Zhou, Limei, Boutros, Paul, Modeno, Piergiorgio, Liang, Muh-Lii, Scherer, Steve W, Bouffet, Eric, Rutka, James T, Pomeroy, Scott L., Lau, Ching C, Taylor, Michael D, Gajjar, Amar, Dirks, Peter B, Hawkins, Cynthia E, Huang, Annie
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431561/
https://ncbi.nlm.nih.gov/pubmed/19962671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.10.025
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