Frequent amplification of a chr19q13.41 microRNA polycistron (C19MC) in aggressive primitive neuro-ectodermal brain tumors

We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45(~25%) primary CNS-PNET which results in striking over-expression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell surviv...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Li, Meihua, Lee, Kyle F, Lu, Yuntao, Clarke, Ian, Shih, David, Eberhart, Charles, Collins, V. Peter, Van Meter, Tim, Picard, Daniel, Zhou, Limei, Boutros, Paul, Modeno, Piergiorgio, Liang, Muh-Lii, Scherer, Steve W, Bouffet, Eric, Rutka, James T, Pomeroy, Scott L., Lau, Ching C, Taylor, Michael D, Gajjar, Amar, Dirks, Peter B, Hawkins, Cynthia E, Huang, Annie
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431561/
https://ncbi.nlm.nih.gov/pubmed/19962671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.10.025
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares