Autocrine Adenosine Signaling Promotes Regulatory T Cell–Mediated Renal Protection

Regulatory T cells (Tregs) suppress the innate inflammation associated with kidney ischemia-reperfusion injury (IRI), but the mechanism is not well understood. Tregs express CD73, the final enzyme involved in the production of extracellular adenosine, and activation of the adenosine 2A receptor (A(2...

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Detalhes bibliográficos
Main Authors: Kinsey, Gilbert R., Huang, Liping, Jaworska, Katarzyna, Khutsishvili, Konstantine, Becker, David A., Ye, Hong, Lobo, Peter I., Okusa, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431416/
https://ncbi.nlm.nih.gov/pubmed/22835488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012010070
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