Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the underlying molecular mechanisms remain unclear. Here, we demonstrate the effectiveness of a novel “top-down” approach for identifying proteins an...

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Detalhes bibliográficos
Main Authors: Wishart, Thomas M., Rooney, Timothy M., Lamont, Douglas J., Wright, Ann K., Morton, A. Jennifer, Jackson, Mandy, Freeman, Marc R., Gillingwater, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431337/
https://ncbi.nlm.nih.gov/pubmed/22952455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002936
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