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The mechanism of the chemical synthesis of oligonucleotides and its synthetic consequences.
The data obtained mainly by pulsed NMR spectroscopy on phosphorus nuclei on the mechanism of the internucleotide phosphodiester (PDE) group formation are summarised. With arylsulphonyl chloride as condensing reagent monomeric nucleotide derivative B (nucleoside metaphosphate or its pyridinium adduct...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1976
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC343123/ https://ncbi.nlm.nih.gov/pubmed/186762 |
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