General scheme of the phosphotriester condensation in the oligodeoxyribonucleotide synthesis with arylsulfonyl chlorides and arylsulfonyl azolides.
Phosphotriester condensation (RO)(R'O)PO-2 (PDE) + R"OH (RO)(R'O)(R"O)PO (PTE) in the presence of arylsulfonyl chloride (ArSO2Cl) as well as arylsulfonyl azolides proceeds in two steps as revealed by 31P NMR spectroscopy. Pyrophosphotetraester (PPTE) accumulates in over 80% yield in the first step a...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1984
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC318643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6701094/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/12.4.2091 |
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