Differential Adaptations of Methicillin-Resistant Staphylococcus aureus to Serial In Vitro Passage in Daptomycin: Evolution of Daptomycin Resistance and Role of Membrane Carotenoid Content and Fluidity

Previous studies showed serial 20 d in vitro passage of MRSA strain MW2 in sublethal daptomycin (DAP) resulted in diverse perturbations in both cell membrane (CM) and cell wall (CW) characteristics, including increased CM rigidity; increased CW thickness; “gain-in-function” single nucleotide polymor...

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Detalhes bibliográficos
Main Authors: Mishra, Nagendra N., Rubio, Aileen, Nast, Cynthia C., Bayer, Arnold S.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431083/
https://ncbi.nlm.nih.gov/pubmed/22956961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/683450
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