Effects of MnDPDP and ICRF-187 on Doxorubicin-Induced Cardiotoxicity and Anticancer Activity

Oxidative stress participates in doxorubicin (Dx)-induced cardiotoxicity. The metal complex MnDPDP and its metabolite MnPLED possess SOD-mimetic activity, DPDP and PLED have, in addition, high affinity for iron. Mice were injected intravenously with MnDPDP, DPDP, or dexrazoxane (ICRF-187). Thirty mi...

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Main Authors: Kurz, Tino, Grant, Derek, Andersson, Rolf GG, Towart, Robertson, De Cesare, Michelandrea, Karlsson, Jan Olof G
格式: Artigo
語言:Inglês
出版: Neoplasia Press Inc. 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431035/
https://ncbi.nlm.nih.gov/pubmed/22937177
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