The combination of olaparib and camptothecin for effective radiosensitization

BACKGROUND: Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme involved in the repair of radiation-induced single-strand DNA breaks. PARP inhibitors such as olaparib (KU-0059436, AZD-2281) enhance tumor sensitivity to radiation and to topoisomerase I inhibitors like camptothecin (CPT). Olaparib...

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Dettagli Bibliografici
Autori principali: Miura, Katsutoshi, Sakata, Koh-ichi, Someya, Masanori, Matsumoto, Yoshihisa, Matsumoto, Hideki, Takahashi, Akihisa, Hareyama, Masato
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430568/
https://ncbi.nlm.nih.gov/pubmed/22524618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-62
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