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Joining of ribooligonucleotides with T4 RNA ligase and identification of the oligonucleotide-adenylate intermediate.

T4 RNA ligase was found to join A-A-A-A-A-A and 32pU-U-U-U in the presence of ATP as cofactor. In this reaction the pyrophosphate of pU-U-U-U and pA was isolated by chromatography on a RPC-5 column, besides the joined product and the starting materials. This pyrophosphate was shown to be an intermed...

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Bibliografske podrobnosti
Main Authors: Ohtsuka, E, Nishikawa, S, Sugiura, M, Ikehara, M
Format: Artigo
Jezik:Inglês
Izdano: 1976
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC343018/
https://ncbi.nlm.nih.gov/pubmed/183186
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