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Crystal structure of the dopamine N-acetyltransferase–acetyl-CoA complex provides insights into the catalytic mechanism

The daily cycle of melatonin biosynthesis in mammals is regulated by AANAT (arylalkylamine N-acetyltransferase; EC 2.3.1.87), making it an attractive target for therapeutic control of abnormal melatonin production in mood and sleep disorders. Drosophila melanogaster Dat (dopamine N-acetyltransferase...

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Autori principali: Cheng, Kuo-Chang, Liao, Jhen-Ni, Lyu, Ping-Chiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429931/
https://ncbi.nlm.nih.gov/pubmed/22716280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120520
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