Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs

Mucopolysaccharidosis VII (MPS VII) is due to deficient β-glucuronidase (GUSB) activity, which leads to accumulation of chondroitin, heparan, and dermatan sulfate glycosaminoglycans in various tissues including those of the spine. Associated spine disease can be due to abnormalities in the vertebrae...

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Main Authors: Smith, Lachlan J, Martin, John T, O'Donnell, Patricia, Wang, Ping, Elliott, Dawn M, Haskins, Mark E, Ponder, Katherine P
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429794/
https://ncbi.nlm.nih.gov/pubmed/22510705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.03.013
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