Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain

Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) are RNA-binding proteins pathogenetically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but it is not known if they regulate the same transcripts. We addressed this question using crosslinkin...

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Detalhes bibliográficos
Main Authors: Rogelj, Boris, Easton, Laura E., Bogu, Gireesh K., Stanton, Lawrence W., Rot, Gregor, Curk, Tomaž, Zupan, Blaž, Sugimoto, Yoichiro, Modic, Miha, Haberman, Nejc, Tollervey, James, Fujii, Ritsuko, Takumi, Toru, Shaw, Christopher E., Ule, Jernej
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429604/
https://ncbi.nlm.nih.gov/pubmed/22934129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00603
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