Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition

Targeting dendritic cells (DC) through the release of suppressive factors is an effective means for tumors to escape immune control. We assessed the involvement of downstream signaling through the JAK2/STAT3 and p38 MAPK pathways in tumor-induced suppression of human DC development. Whereas the JAK2...

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Autori principali: Oosterhoff, Dinja, Lougheed, Sinéad, van de Ven, Rieneke, Lindenberg, Jelle, van Cruijsen, Hester, Hiddingh, Lotte, Kroon, Jan, van den Eertwegh, Alfons J.M., Hangalapura, Basav, Scheper, Rik J., de Gruijl, Tanja D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429569/
https://ncbi.nlm.nih.gov/pubmed/22934257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20365
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