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Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation

Autophagy is a catabolic process involved in the turnover of organelles and macromolecules which, depending on conditions, may lead to cell death or preserve cell survival. We found that some lung cancer cell lines and tumor samples are characterized by increased levels of lipidated LC3. Inhibition...

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Main Authors: Kaminskyy, Vitaliy O., Piskunova, Tatiana, Zborovskaya, Irina B., Tchevkina, Elena M., Zhivotovsky, Boris
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429541/
https://ncbi.nlm.nih.gov/pubmed/22562073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.20123
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