Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation

Macroautophagy/autophagy inhibition under stress conditions is often associated with increased cell death. We found that under nutrient limitation, activation of CASP8/caspase-8 was significantly increased in autophagy-deficient lung cancer cells, which precedes mitochondria outer membrane permeabil...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Allavena, Giulia, Cuomo, Francesca, Baumgartner, Georg, Bele, Tadeja, Sellgren, Alexander Yarar, Oo, Kyaw Soe, Johnson, Kaylee, Gogvadze, Vladimir, Zhivotovsky, Boris, Kaminskyy, Vitaliy O
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
Soggetti:
Research Papers - Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902222/
https://ncbi.nlm.nih.gov/pubmed/29165042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1405192
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