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Targeting pre-miRNA by Peptide Nucleic Acids: A new strategy to interfere in the miRNA maturation

PNAs conjugated to carrier peptides have been employed for the targeting of miRNA precursor, with the aim to develop molecules able to interfere in the pre-miRNA processing. The capability of the molecules to bind pre-miRNA has been tested in vitro by fluorescence assayes on Thiazole Orange labeled...

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Detalhes bibliográficos
Main Authors: Avitabile, Concetta, Saviano, Michele, D'Andrea, Luca, Bianchi, Nicoletta, Fabbri, Enrica, Brognara, Eleonora, Gambari, Roberto, Romanelli, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429535/
https://ncbi.nlm.nih.gov/pubmed/22699795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.20911
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