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The mechanism of DNA breakage by phleomycin in vitro.
Phleomycin induces DNA breakage in vitro in the presence of the sulphydryl compound dithiothreitol. The reaction appears to be free radical-mediated, and requires oxygen and metal ions. Reaction rate is limited by the concentration of oxygen, which is converted to hydrogen peroxide during DNA breaka...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1976
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC342953/ https://ncbi.nlm.nih.gov/pubmed/818624 |
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