AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure

BACKGROUND: Histidine-rich calcium binding protein (HRC) is located in the lumen of sarcoplasmic reticulum (SR) that binds to both triadin (TRN) and SERCA affecting Ca(2+) cycling in the SR. Chronic overexpression of HRC that may disrupt intracellular Ca(2+) homeostasis is implicated in pathogenesis...

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Detalhes bibliográficos
Main Authors: Park, Chang Sik, Cha, Hyeseon, Kwon, Eun Jeong, Jeong, Dongtak, Hajjar, Roger J., Kranias, Evangelia G., Cho, Chunghee, Park, Woo Jin, Kim, Do Han
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429470/
https://ncbi.nlm.nih.gov/pubmed/22952658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043282
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