Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

BACKGROUND: The CD44 transmembrane glycoproteins play multifaceted roles in tumor progression and metastasis. CD44 expression has also been associated with stem-like breast cancer cells. Hypoxia commonly occurs in tumors and is a major cause of radiation and chemo-resistance. Hypoxia is known to inh...

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Main Authors: Krishnamachary, Balaji, Penet, Marie-France, Nimmagadda, Sridhar, Mironchik, Yelena, Raman, Venu, Solaiyappan, Meiyappan, Semenza, Gregg L., Pomper, Martin G., Bhujwalla, Zaver M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429433/
https://ncbi.nlm.nih.gov/pubmed/22937154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044078
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