Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

Childhood herpes simplex virus-1 (HSV-1) encephalitis (HSE) may result from single-gene inborn errors of TLR3 immunity. TLR3-dependent induction of IFN-α/β or IFN-λ is crucial for protective immunity against primary HSV-1 infection in the central nervous system (CNS). We describe here two unrelated...

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Auteurs principaux: Herman, Melina, Ciancanelli, Michael, Ou, Yi-Hung, Lorenzo, Lazaro, Klaudel-Dreszler, Maja, Pauwels, Elodie, Sancho-Shimizu, Vanessa, Pérez de Diego, Rebeca, Abhyankar, Avinash, Israelsson, Elisabeth, Guo, Yiqi, Cardon, Annabelle, Rozenberg, Flore, Lebon, Pierre, Tardieu, Marc, Heropolitańska-Pliszka, Edyta, Chaussabel, Damien, White, Michael A., Abel, Laurent, Zhang, Shen-Ying, Casanova, Jean-Laurent
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428952/
https://ncbi.nlm.nih.gov/pubmed/22851595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111316
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