Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion

Salicylidene acylhydrazides belong to a class of compounds shown to inhibit bacterial type III secretion (T3S) in pathogenic Gram-negative bacteria. This class of compounds also inhibits growth and replication of Chlamydiae, strict intracellular bacteria that possess a T3S system. In this study a li...

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Bibliografiske detaljer
Main Authors: Ur-Rehman, Tofeeq, Slepenkin, Anatoly, Chu, Hencelyn, Blomgren, Anders, Dahlgren, Markus K, Zetterström, Caroline E, Peterson, Ellena M, Elofsson, Mikael, Gylfe, Åsa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428607/
https://ncbi.nlm.nih.gov/pubmed/22669447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2012.43
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