Polymalic Acid–Based Nanobiopolymer Provides Efficient Systemic Breast Cancer Treatment by Inhibiting both HER2/neu Receptor Synthesis and Activity

Biodegradable nanopolymers are believed to offer great potential in cancer therapy. Here, we report the characterization of a novel, targeted, nanobiopolymeric conjugate based on biodegradable, nontoxic, and nonimmunogenic PMLA [poly(β-l-malic acid)]. The PMLA nanoplatform was synthesized for repeti...

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Détails bibliographiques
Auteurs principaux: Inoue, Satoshi, Ding, Hui, Portilla-Arias, Jose, Hu, Jinwei, Konda, Bindu, Fujita, Manabu, Espinoza, Andres, Suhane, Sonal, Riley, Marisa, Gates, Marcus, Patil, Rameshwar, Penichet, Manuel L., Ljubimov, Alexander V., Black, Keith L., Holler, Eggehard, Ljubimova, Julia Y.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428373/
https://ncbi.nlm.nih.gov/pubmed/21303974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3093
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