Endothelial Expression of TNF Receptor-1 Generates a Pro-apoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Activation of TNF-receptor 1 (TNF-R1) can generate signals that promote either apoptosis or survival. In this study, we show that these signals can be determined by the character of the extracellular matrix in the tumor microenvironment. Specifically, through studies of glioblastoma we showed that T...

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Autors principals: Huang, Ping, Rani, M. R. Sandhya, Ahluwalia, Manmeet S., Bae, Eunnyung, Prayson, Richard A., Weil, Robert J., Nowacki, Amy S., Hedayat, Hirad, Sloan, Andrew E., Lathia, Justin D., Rich, Jeremy N., Tipps, Russell, Gladson, Candece L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428239/
https://ncbi.nlm.nih.gov/pubmed/22396498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2621
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